ABSTRACT Starting from ibuprofen, a non-steroidal anti-inflammatory drug, N,N’-disubstituted thiourea derivatives were synthesized by refluxing the acid chloride of ibuprofen with potassium thiocyanate followed by substituted anilines to get N-2-(4-(2-methylpropyl)phenyl)propionoyl-N’-(2’-bromophenyl) thiourea (1), N-2- (4-(2-methylpropyl)phenyl)propionoyl-N’-(2’-chlorophenyl) thiourea (2) and N-2-(4-(2-methylpropyl)phenyl)propionoyl-N’-(3’,4’-dichlorophenyl) thiourea (3). Metal complexes (4-15) of (1-3) were synthesized by refluxing it with one equivalence salts of Co (ΙΙ), Ni(II), Pb(II) and Cu(I). Structures of all the synthesized thiourea ligands and their metal complexes were determined by FTIR and 1HNMR spectroscopy. Shift in stretching frequency in FTIR and resonance frequency in 1HNMR spectroscopic data suggested that the ligands and metal are coordinated to afford respective metal complexes M[L]n. The synthesized compounds were tested against urease enzyme and the results were compared with standard thiourea, as positive control. Most of the investigated compounds showed potential inhibitory activity against Jack bean urease. Compound 5 was found to be the most potent urease inhibitor with IC50 of 14.6 μΜ, whereas compounds 8, 11 and 12 possessed potent urease inhibition. The tested compounds can be taken as lead molecules for gastrointestinal ulcer therapy.

Abstract Technological advancements in various domains have broadened the application horizon of robotics to an incredible extent. Highlighting a very recent application area, this paper presents a comprehensive review of robotics application in food industry. Robots essentially have the potential to transform the processes in food processing and handling, palletizing and packing and food serving. Therefore, recent years witnessed tremendously increased trend of robots deployment in food sector. Consequently, the aspects related with robot kinematics, dynamics, hygiene, economic efficiency, human-robot interaction, safety and protection and operation and maintenance are of critical importance and are discussed in the present review. A comparison of actual robots being used in the industry is also presented. The review reveals that the food serving sector is the new potential area in which ample research opportunities exist by integrating advancements from various technology domains. It is anticipated that wider dissemination of research developments in ‘robo-food’ will stimulate more collaborations among the research community and contribute to further developments.

Resumo O ajuste contínuo de propofol na administração manual de anestesia para um procedimento cirúrgico onera a carga de trabalho de anestesistas que trabalham em ambiente multitarefa. Indo além da administração manual e da infusão alvo-controlada (IAC), o controle de circuito fechado da infusão de propofol tem o potencial de oferecer vários benefícios em termos de manejo das perturbações e reduzir o efeito da variabilidade interpaciente. Este artigo propõe uma abordagem para a administração automatizada de drogas em circuito fechado para controlar a profundidade da hipnose (PDH) em anestesia. Em contraste com a maioria das pesquisas existentes sobre o controle da anestesia que usam estratégias de controle linear ou de suas variantes melhoradas, a novidade da presente pesquisa reside na aplicação de uma estratégia de controle consistente; isto é, o Controle por Modos Deslizantes (CMD) para controlar com precisão a infusão da droga. Com base no modelo derivado do paciente, o controlador projetado usa as medições do EEG para regular a PDH no Bispectral Index (BIS), controla a taxa de infusão de propofol. O desempenho do controlador é investigado e caracterizado com um conjunto de dados reais de oito pacientes submetidos à cirurgia. Os resultados deste estudo in silico indicam que, para todos os pacientes, com 0% de excesso observado, o erro de estado estacionário fica entre ± 5. Clinicamente, isso implica que em todos os casos, sem qualquer sobredosagem, o controlador mantém o nível desejado de PDH para a condução tranquila dos procedimentos cirúrgicos.

Abstract Continuous adjustment of Propofol in manual delivery of anesthesia for conducting a surgical procedure overburdens the workload of an anesthetist who is working in a multi-tasking scenario. Going beyond manual administration and Target Controlled Infusion, closed-loop control of Propofol infusion has the potential to offer several benefits in terms of handling perturbations and reducing the effect of inter-patient variability. This paper proposes a closed-loop automated drug administration approach to control Depth Of Hypnosis in anesthesia. In contrast with most of the existing research on anesthesia control which makes use of linear control strategies or their improved variants, the novelty of the present research lies in applying robust control strategy i.e. Sliding Mode Control to accurately control drug infusion. Based on the derived patient's model, the designed controller uses measurements from EEG to regulate DOH on Bispectral Index by controlling infusion rate of Propofol. The performance of the controller is investigated and characterized with real dataset of 8 patients undergoing surgery. Results of this in silico study indicate that for all the patients, with 0% overshoot observed, the steady state error lies in between ±5. Clinically, this implies that in all the cases, without any overdose, the controller maintains the desired DOH level for smooth conduction of surgical procedures.

Dados los largos tiempos de recorrido y las severas limitaciones medioambientales en un planeta como Marte, ahora la única opción factible es observar y explorar el planeta a través de vehículos planetarios más sofisticados. Para lograr los objetivos de misiones cada vez más ambiciosas bajo tales condiciones extremas, los vehículos deben tener autonomía. Una mayor autonomía, obviamente, depende de la calidad de estimaciones del estado del vehículo, por ejemplo, su posición y su orientación relativa a un punto de referencia inicial. Esta investigación presenta un método de estimación de estado basado en el Filtro Extendido Kalman (EKF) para combinar la distancia de la odometría y la orientación dada por Unidad de Medida Inercial (IMU), y atenuando así los errores generados por el uso individual de cualquier de estos sistemas. Para simular un método basado en sensores solares para correcciones absolutas, se usó un compás magnético para dar datos absolutos de las actualizaciones de dirección. La técnica fue implementada en MotherBot, un vehículo especialmente diseñado con dirección deslizante. Los resultados experimentales validaron la aplicación de la estrategia de estimación propuesta. Se mostró un rango de error dentro del 3% de la distancia recorrida en comparación con un error aproximado del 8% obtenido de la combinación directa.

Given the long traverse times and severe environmental constraints on a planet like Mars, the only option feasible now is to observe and explore the planet through more sophisticated planetary rovers. To achieve increasingly ambitious mission objectives under such extreme conditions, the rovers must have autonomy. Increased autonomy, obviously, relies on the quality of estimates of rover's state i.e. its position and orientation relative to some starting frame of reference. This research presents a state estimation approach based on Extended Kalman Filter (EKF) to fuse distance from odometry and attitude from an Inertial Measurement Unit (IMU), thus mitigating the errors generated by the use of either system alone. To simulate a Sun-sensor based approach for absolute corrections, a magnetic compass was used to give absolute heading updates. The technique was implemented on MotherBot, a custom-designed skid steered rover. Experimental results validate the application of the presented estimation strategy. It showed an error range within 3% of the distance travelled as compared to about 8% error obtained from direct fusion.

Uma nova série de 4-amino-5-aril-3H-1,2,4-triazol-3-tionas, tendo vários grupos metoxibenzila e metoxifenila, foi sintetizada através de refluxo de sais de hidrazina carboditioato de potássio em solução aquosa diluída de hidrato de hidrazina. Estes sais foram formados pela reação de hidrazinas ácidas e dissulfeto de carbono em solução de hidróxido de potássio metanólico a 0-5 ºC. 4-Amino-5-aril-3H-1,2,4-triazol-3-tionas foram condensadas com diferentes ácidos aromáticos substituídos para produzir 1,2,4-triazol[3,4-b]1,3,4-tiodiazols 3,6-disubstituídos. As estruturas dos compostos sintetizados foram caracterizadas pelas espectroscopias no infravermelho (IR) e ressonância magnética nuclear (NMR) de ¹H e 13C, análise elementar e espectrometria de massa (MS). Todos os compostos sintetizados foram examinados com relação as suas atividades de inibição de urease, antioxidante e antibacteriana. Alguns compostos mostraram excelente atividade de inibição de urease, mais do que a droga padrão. Outros compostos apresentaram potente atividade antioxidante. Todos os compostos mostraram atividades antibacterianas significativas em comparação com a droga padrão.

A new series of 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones, bearing various methoxybenzyl- and methoxyphenethyl groups, was synthesized by refluxing potassium hydrazinecarbodithioate salts in dilute aqueous solution of hydrazine hydrate. These salts were formed by the reaction of acid hydrazides and carbon disulfide in methanolic potassium hydroxide solution at 0-5 °C. 4-Amino-5-aryl-3H-1,2,4-triazole-3-thiones were condensed with different substituted aromatic acids to yield 3,6-disubstituted-1,2,4-triazolo[3,4-b]1,3,4-thiadiazoles. The structures of the synthesized compounds were characterized by infrared (IR), ¹H and 13C nuclear magnetic resonance (NMR), elemental analysis and mass spectrometric (MS) studies. All the synthesized compounds were screened for their urease inhibition, antioxidant and antibacterial activities. Some compounds showed excellent urease inhibition activity, more than the standard drug. Others exhibited potent antioxidant activity. All the compounds showed significant antibacterial activities as compared to the standard drug.